In collaborations with microbiologists a large number of new biologically active natural products have been isolated and purified. Their structures were determined by modern NMR and MS equipment. The metabolites reutericyclin, omphalotin and cyclosporins were chemically synthesized. New analogs of vancomycins were prepared by novel biosynthetic approaches, and the ribosomal biosynthesis of the omphalotin precursor and subsequent enzymatic modifications were elucidated (R. D. Süßmuth).
Omphalotin A
Cyclodecapeptide with 9 N-methylations from the basidiomycete Omphalotus olearius
A. Höltzel, M.G. Gänzle, G.J. Nicholson, W.P. Hammes, and G. Jung (2000). The First Low Molecular Weight Antibiotic from Lactic Acid Bacteria: Reutericyclin, a New Tetramic Acid, Angew. Chem. 112, 2886-2888, Angew. Chem. Int. Ed. Engl. 39, 2766-2768.
D. Bischoff, S. Pelzer, B. Bister, G. J. Nicholson, S. Stockert, M. Schirle, W. Wohlleben, G. Jung, and R.D. Süßmuth (2001). The Biosynthesis of Vancomycin-Type Glycopeptide-Antibiotics-The Order of the Cyclization Steps, Angew. Chem. 113, 4824-4827; Angew. Chem. Int. Ed. Engl. 40, 4688-4691.
D. Bischoff, S. Pelzer, A. Höltzel, G. Nicholson, S. Stockert, W. Wohlleben, G. Jung, and R.D. Süssmuth (2001). The Biosynthesis of Vancomycin-type Glycopeptide Antibiotics – New Insights into the Cyclization Steps, Angew. Chem. 113, 1736-1739; Angew. Chem. Int. Ed. Engl. 40, 1693-1696.
S. Weist, B. Bister, O. Puk, D. Bischoff, S. Pelzer, G.J. Nicholson, W. Wohlleben, G. Jung, and R.D. Süssmuth (2002). Fluorobalhimycin – A New Chapter in Glycopeptide Antibiotic Research, Angew. Chem. 114, 3531-3534; Angew. Chem. Int. Ed. Engl. 41, 3383-3385.
B. Thern, J. Rudolph, and G. Jung (2002). First Total Synthesis of the Nematicidal Cyclododecapeptide Omphalotin A by Using Racemization-free Triphosgene-Mediated Couplings in the Solid Phase, Angew. Chem. 114, 2401-2403; Angew. Chem. Int. Ed. Engl. 41, 2307-2309.
A. Höltzel, D.G. Schmid, G.J. Nicholson, S. Stevanovic, J. Schimana, K. Gebhardt, H.-P. Fiedler, and G. Jung (2002). Arylomycins A and B, New Biaryl-bridged Lipopeptide Antibiotics Produced by Streptomyces sp. Tü 6075, J. Antibiotics 55, 571-577.
A. Höltzel, R.W. Jack, G.J. Nicholson, G. Jung, K. Gebhardt, H.-P. Fiedler, and R. D. Süssmuth (2001). Streptocidins A,D, Novel Cyclic Decapeptide Antibiotics Produced by Streptomyces sp. Tü6071. II. Structure Elucidation, J. Antibiotics 54, 434-440.
J.F. Blom, B. Bister, D. Bischoff, G. Nicholson, G. Jung, R.D. Süssmuth, and F. Jüttner (2003). Oscillapeptin J, a New Grazer-Toxin of the Freshwater Cyanobacterium Planktothrix rubescens, J. Nat. Prod. 66, 431-434.
P.G. Becher, S. Keller, G. Jung, R.D. Süssmuth, and F. Jüttner (2007). Insecticidal Activity of 12-epi-Hapalindole J Isonitrile: A New Bioactivity of Hapalindoles, Phytochemistry 68, 2493-2497.
H.I. Baumann, S. Keller, F.E. Wolter, G.J. Nicholson, G. Jung, R.D. Süssmuth, and F. Jüttner (2007). Planktocyclin, a Cyclooctapeptide Protease Inhibitor Produced by the Freshwater Cyanobacterium Planktothrix rubescens, J. Nat. Prod. 70, 1611-1615.
Prof. Günther Jung 