Patents

Prof. Dr. Günther Jung, cooperation partners and coworkers filed patents in the following areas:

• Lipopeptide-Adjuvants, Lipopeptide Vaccines with B-, T-Helper- und CTL-response
• Sequence motifs of isolated self-peptides which bind to MHC-I and II
• Epitope mapping of viral proteins for diagnostic and vaccine development
• Methods for the preparation of sensor surfaces and microstructured  peptides
• Biologically active microbial metabolites; Isolation, Structure, Biosynthesis of antibiotics such as lantibiotcs, vancomycins and omphalotins
• Siderophores: Isolation and structure
• Synthesis of hormones and analogues such as neuropeptide Y and somatostatin
• Synthesis of gene transfer reagents
• Chemical synthesis, Reagents, Coupling methods

Patents

1. Decapeptide and its use (Interferon)
Jung, G.; Brueckner, H.; Swetly, P. Bozler, G.
Thomae, Dr. Karl, G.m.b.H. (1980).
EP: 81-108535 811020
OE: 80-3040824 801030

2. Tridecapeptide and its use (Interferon)
Jung, G.; Brueckner, H.; Swetly, P.; Bozler, G.
Thomae, Dr. Karl, G.m.b.H. (1980).
EP: 81-108536 811020, US Pat. 4376760 (15.03.1983)
OE: 80-3040825 801030

3. Culture broth containing amiclenomycin derivatives, extract, active substance mixture, antibiotic amiclenomycin derivatives, their salts, an antibiotic containing these active substances, and s new microorganism
Werner, R-G.; Lechner, U.; Appel, K. R; Goeth, H.; Zaehner, H.; Poetseh, M.; Jung, G.; Kern, A.
Thomae, Dr. Karl, G.m.b.H. (1983)
DE 83-3339423 831029

4. Peptide antibiotic epidermin
Werner, R-G.; Zaehner, H.; Jung, G.; Allgaier, H., Schneider, U.
Thomae, Dr. Karl, G.m.b.H. (1984)
DE 84-3440423 841106

5. Dicarbonsäuremonohydrazid-Derivate
Jung, G., Christner, J.
Thomae, Dr. Karl, G.m.b.H. (1985)
OPA 34 17413.3

6. Preparatlon of somatostatin derivatives for treatment of diabetes mellitus and gastrointestinal ailments
Jung, G.,
Diamalt A.-G. (1985)
DE 3522638 (25.06.85/19.08.87/28.11.90)
EP 0 232 284

7. Antibiotic polypeptide and its use
Werner, R-G. Zaehner, H.; Jung, G.; Allgaier, H.; Schneider, U.
Thomae, Dr. Karl, G.m.b.H. (1985)
EP:85-113908 851031
DE: 85-3523478 850701

8. Chemical or microbial synthesis of rhizocticine antibiotics
Loeffler, W.; Kugler, M.; Jung, G.; Kern, A; Rapp, C.
Ciba-Geigy A-G. (1986)
EP 87-114616 871007
DE 86-3634437 861009

9. Preparation of lipophilic amino acid derivatives as immune adjuvants
(Neue Immunogene, Verfahren zu ihrer Herstellung, Reinigung und Verwendung)
Jung, G.; Metzger, J.
Hoechst A-G. (1987)
DE P 35 22 512.2 (24.06.85)
DE 87-3700173  870105

10. Membrananker-Wirkstoffkonjugat
Seine Herstellung sowie seine Verwendung
Jung, G.; Metzger, J.; Wiesmüller, H.-K., u.a.
Hoechst A-G. (1987)
DE P 3546 150.0 (27.12.85/22.01.87)

11. Neuropeptide Y and antioanalogs as cardiovascular agents and antiobesity agents
Jung, G.; Beck, A. Schnorrenberg, G.; Gaida, W., Lang, R.
Boehringer Ingelheim K.-G. (1988)
DE 88-3811193 880401

12. Antibiotic
Jung, G.; Kellner, R, Zähner, H.; Götz, F.; Hörner, T.; Werner, R G.; AlIgaier, H.
Thomae, Dr. Karl, G.m.b.H. (1989)
EP 89-108350 890510

13. Manufacture of epidermin with Staphylococcus epidermidis and its isolation and purification
Werner, R-G.; Zaehner, H.; Jung, G.; Hoerner, T.; Kellner, R; Fiedler, H. P.
Thomae, Dr. Karl, G.m.b.H. (1989)
EP 89-112446 890707
US 88-219698 880715

14. Recombinant manufacture of polypeptides containing dehydroamino acids and lanthionine bridges with bacteria
Jung, G.; Kellner, R, Entian, K. 0.; Schnell, N.; Kaletta, C.; Goetz, F.; Werner, R G.,
Allgaier, H .
Thomae, Dr. Karl, G.m.b.H. (1989)
EP 89-108907.0 (18.05.89), Publication 11.05.94, EP Nr. 0342658 B1
GB 88-11761 880518

15. Synthetic vaccines against foot-and-mouth disease
Wiesmueller, K.-H.; Hess, G.; Jung, G.
Hoechst A.-G. (1988)
EP 89-106628 890413
DE 88-3813821 880422

16. Manufacture of a novel microbicidal chlorocyclohexenonyl alanine derivative with Bacillus subtilis
Jung, G.; Loeffler, W.; Rapp, C.; Katzer, W.; Petersen, F.
Bayer A.-G. (1988)
DE 88-3834662 881012

17. Synthetic vaccines for specific induction of killer T -Iymphocytes (lipopep-
 tides)
Jung, G., Rammensee, H.G., Deres, K., Wiesmüller, K.H.
Hoechst AG, Germany (1989)
DE: 89-3937412.2 (10.11.1989)

18. N-Acyl-S-(2-hydroxyalkyl)-cysteines, their preparation and their use as intermediates in the preparation of synthetic immunoadjuvants and synthetic vaccines
Metzger, J., Wiesmüller, K.-H., Jung, G.
Hoechst AG, Germany (1991 )
EP: 92-109834 920611
DE: 91-4119856910617 (17.06.91/11.06.92)

19. Hepatitis C virus (HCV) peptide antigens and method for determination of HCV
Seidel, C., Ehrlich-Weinreich, G., Bayer, H., Wienhues, U.H., Jung, G.G., Ihlenfeldt, H.G.
Boehringer Mannheim GmbH, Germany (1991)
DE: 91-4141304 911214

20. Determination of allele-speeifie peptide sequenees on MHC antigens
Rammensee, H.-G., Falk, K., Roetzschke, 0., Stevanovic, S., Jung, G.
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Germany (1991)
DE: 91-4116256 910517 (17.5.1991)
EC: 0584 136 (92 909 723.6)
US: 5747269

21. Method for determination of MHC allele-specifie peptides and use of these peptides for diagnosis and therapy
Roetzschke, 0., Falk, K., Stevanovic, S., Jung, G., Rammensee, H.-G
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Germany (1992)
DE: 92-4238416.8 (13.11.1992)
EU: 0669001 (94900 137.4)
US: 08424,484 (1.9.1995)

22. Hepatitis C virus peptide antigens and a method of detecting the virus
Seidel, C., Wienhues-Thelen, U.-H., Bayer, H., Jung, G.-G., Ihlenfeldt, H.G.
Roche Diagnostics GmbH
EP: 93-112337930802 (9911 3825.6-2110) (02.08.1993)
DE: 92-4240980921205 (07.08.1992; 05.12.1992)

23. Preparation of lipopeptides useful as drugs, in preparation of antibodies and vaccines, and in affinity chromatography
Rapp, W., Jung, G., Wiesmüller, K.-H.
Rapp Polymere, Germany (1993)
DE: 93-4329309 930831

24. Preparation of neuropeptide Y antagonists
Beck-Sickinger, A., Rudolf, K., Eberlein, W., Engel, W., Jung, G., Willim, K.-O., Wieland,
H. A., Doods, H.
Dr. Karl Thomae GmbH, Germany (1993)
DE: 93-4311756930408

25. Nucleic acid transfer peptides and their use for including nucleic acids in eukaryotic cells
Moelling, K., Surovoy, A., Dannull, J., Jung, G.
Boehringer Mannheim GmbH, Germany (1993), Roche Pharma
WO 94-EP1147 940413, OE 4412629
EP: 93-4318470930603
EP:0693939

26. Nukleinsäure-Transfer-Peptide und deren Verwendung zur Einschleußung von Nukleinsäuren in eukaryontische Zellen
Surovoy, A., Jung, G.
Boehringer Mannheim GmbH, Germany
DE P 4312131.4 (14.04.93)
DE P 4318470.7 (03.06.93)
EU : 94913594.1-2106

27. Cyclic hexapeptides, their synthesis, and their use in treatment of allergies and infections
Henke, S., Jordan, B., Knolle, J., Lauffer, L., Feiertag, S., Wiesmüller, K.-H., Jung, G.
Hoechst AG, Germany (1994)
EP: 0717048 A1
DE: 4444260 A1 (13.12.94)

28. Peptide antigen-specific, activated T-Iymphocytes, their detection and diagnostic and therapeutic appllcatlon
(Antigen-spezifische, aktivierte T-Lymphozyten, Nachweis und Anwendung)
Endl, J., Stahl, P., Albert, W., Jung, G.G., Schendel, D., Meinl, E., Dornmair, K.
Boehringer Manheim GmbH, Germany (1994)
DE: 94-4403522940204 (auch EU, USA, Japan)

29. Skin test for diabetes and other autoimmune diseases
Endl, J., Ganz, M., Stahl, P., Kientsch-Engel, R., Jung, G.G., Pozzilli, P., Donie, F.
Boehringer Mannheim, GmbH, Germany (1995)
DE: 95-19526561 950720

30. Peptides and peptide derivatives from glutamic acid decarboxylase for the early diagnosis and treatment of type I diabetes
(Autoreaktive Peptide aus der humanen Glutaminsäuredecarboxylase (GA))
Endl, J., Stahl, P., Albert, W., Schendel, D., Boitard, C., van Endert, P., Jung, G.G.
Boehringer Mannheim GmbH, Germany (1995), Roche Diagnostics
DE: 95-19525784 950714 (14.07.95/15.07.96)

31. Substituierte N-(Carboxymethyl)-imidazolidindione aus Aminosäuren
Bauser, M., Jung, G. (1997)
Patentantrag eingereicht am 29.9.1997

32. Lipidverbindungen und deren Verwendung z.B. in Liposomen (liposomen Gentransfer)
Surovoy, A., Jung, G.
DE P Appl. 1960 05 175.4 (13.02.96)
EP 97 904417.9-2103 (12.02.1997), PCT / EP 97/00629 (12.02.97)

33. New Lead Substances and Their Use as Therapeutics (” Thiollakton”)
Otto, M., Suessmuth, R, Jung, G., Goetz, F.
Filed 24.12.1998, AH. Docket No. 3277-101 P

34. Biosensoren aus Cyclopeptiden
Göpel, W., Jung, G., Kunz, R, Leipert, 0., Weiß, T.
Creavis (Degussa/Hüls) GmbH
Anm. DE 19824959.4 (04.06.98)

35. Substituierte 2 Sulfonyl-2,3-dihydro-1 H-benzo[c]azepin-4-carbonsäuren
Jung, G., Richter, H.
DE (Roche Ref. 7637 -GT) (23.12.1998)

36. Transfer of mRNA
Jung, G., Rammensee, H.-G., Hoerr, I., Obst, R
EP 9911.7771.8 (09.09.1999)

37. Neue Glycopeptid-Antibiotika und Verfahren zu deren Synthetisierung
Süssmuth, R, Wohlleben, W., Jung, G.
Akz. 10207347.3,18.02.2002 DE

38. Verfahren zur Herstellung von Carbonsäureamiden
Rudolph, J., Jung, G., Thern, B.
Bayer AG, Leverkusen
WO 02/076927A2 (03.10.2002)

39. Triazenverbindungen sowie deren Verwendung
Rademann, J., Smerdka, J., Jung, G.
Merck Patent GmbH
WO 02/055486 A2 (18.07.02/18.07.02)

40. Oxoammoniumsalze sowie deren Verwendung
Rademann, J., et al.
Merck Patent GmbH
DE 101 13 710.9 (16.03.01)

Note: This list is not complete